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Eye ointment 1%

Tetracycline in the form of an eye ointment is applied topically. The drug is laid over the eyelid. How to Buy Tetracycline Capsules 500 mg with No Prescription A single dose is a strip of ointment 0.5-1 cm long.

With trachoma, the ointment is laid every 2–4 hours or more often for 1–2 weeks. With a decrease in inflammation, the frequency of use of Tetracycline decreases to 2-3 times a day. The general course of treatment is 1-2 months. With blepharoconjunctivitis and blepharitis, the ointment is used 3-4 times a day. The course of treatment is 5-7 days.

With keratoconjunctivitis and keratitis, the frequency of use of the drug is 2-3 times a day, and the course of treatment is 5-7 days. In the absence of improvements on the 3rd – 5th day of therapy, it is necessary to consult a doctor.

With barley, an eye ointment is laid at night. Duration of the course - until the signs of inflammation disappear.

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Contraindications

The drug can not be prescribed to pregnant and lactating women, as well as children under the age of eight. In addition, tetracycline is contraindicated in persons suffering from:

  • mycoses;
  • liver failure;
  • leukopenia;
  • hypersensitivity to the components of the tablets.

Caution and medical supervision requires the use of the drug in patients with impaired liver function

Doxycycline (Vibramycin, Unidox Solutab)

Doxycycline is the best tetracycline antibiotic to date. Significantly superior to tetracycline in activity against pneumococci and much better tolerated.

Doxycycline is better absorbed than tetracycline, bioavailability ranges from 90-100%, and is practically independent of food. High levels are achieved in bronchial secretions, sinuses, bile, prostate gland.

Like other antibiotics from the tetracycline group, it passes poorly through the BBB. It is almost completely excreted through the gastrointestinal tract, therefore, doxycycline, unlike tetracycline, can be used for renal failure. Has the longest half-life among tetracyclines from 15-24 hours.

Doxycycline activity spectrum

  • Gram-positive cocci: staphylococci, streptococci, however, currently there is a high resistance of pneumococci, GBSA and most staphylococci.
  • Gram-positive sticks: Listeria, anthrax pathogens.
  • Gram-negative cocci: M. catarrhalis.
  • Gram-negative bacilli: yersinia, campylobacter, brucella, H.influenzae, H.ducreyi, cholera vibrio, plague pathogens, tularemia.
  • Anaerobes: clostridia (except C. difficile), fusobacteria.
  • Spirochetes.
  • Rickettsia.
  • Chlamydia.
  • Mycoplasmas.
  • Actinomycetes.
  • Protozoa: P.falciparum.
  • Many strains of E. coli, Salmonella and Shigella are resistant.
  • Enterococci resistant.
  • Gonococci are most often resistant.
  • Most B.fragilis strains are resistant.

Indications for doxycycline

Infectious and inflammatory diseases caused by microorganisms sensitive to doxycycline.

  1. Infections of the respiratory system and ENT organs.
  2. Gastrointestinal infections.
  3. Purulent infections of the skin and soft tissues (acne).
  4. Infections of the genitourinary system (gonorrhea, primary and secondary syphilis).
  5. Typhus.
  6. Brucellosis.
  7. Rickettsioses.
  8. Osteomyelitis.
  9. Trachoma.
  10. Chlamydia.

Side effects of doxycycline

  1. General catabolic effect, inhibition of protein metabolism, hyperazotemia.
  2. Dyspeptic phenomena, esophagitis.
  3. Inhibition of normal microflora of the gastrointestinal tract and vagina; superinfection, including candidiasis of the gastrointestinal tract and vagina.
  4. In children, a violation of the formation of bone and dental tissue: discoloration of teeth, defects in enamel, slowing down the longitudinal growth of bones.
  5. Photosensitivity (more often doxycycline).
  6. Hepatotoxicity, up to necrosis of liver tissue - especially with liver pathology and rapid intravenous administration.
  7. Pseudotumor brain syndrome: increased intracranial pressure with prolonged use.
  8. Nephrotoxicity: development of tubular necrosis when using expired drugs.

Mode of application

Inside and intravenously (slowly, over 1 hour) 0.2 g every 12 hours. The dosage regimen with a loading dose (0.2 g) on ​​the first day and subsequent administration of 0.1 g per day is outdated.

Children over 8 years old

Inside and intravenously - 5 mg per 1 kg of the child’s body weight (not more than 0.2 g per day in 1-2 doses (administration). In children weighing more than 45 kg, the doses are similar to adults.

Doxycycline is not used in children under 8 years of age, since tetracycline antibiotics (including doxycycline) cause a long-term discoloration of the teeth, enamel hypoplasia and a slowdown in the longitudinal growth of skeleton bones in this category of patients.

Release Forms

Doxycycline is available in capsules and tablets of 0.05 g and 0.1 g, also in the form of syrup and powder for the preparation of an infusion solution in 0.1 g vials.

Pharmacokinetics

Up to 20% of the substance excreted through the kidneys

The penetration of a substance into the blood is almost 77%. http://www.webmd.com/drugs/2/drug-5919/tetracycline-oral/details Eating helps to reduce this indicator. The ability to bind to proteins in the blood plasma is from 55% to 65%. 2-3 hours after the use of the drug, the maximum content of the active substance in the patient’s blood is reached, over the next 8 hours, its concentration decreases.

A small amount of the substance is metabolized in the tissues of the liver. The half-life of the drug takes 6-11 hours. After 2 hours after use, the active substance is found in laboratory urine. Up to 20% of the substance is excreted through the kidneys in the first 12 hours after its intake.

Oral tetracycline tablets, when ingested in the small intestine, are absorbed into the bloodstream quite quickly and almost without residue. The distribution of the active substance in the body is uneven. It mainly accumulates in the lungs, nodes of the lymphatic system, spleen.

Almost half of the dosage of the drug is metabolized with the help of liver tissue cells, while inactive decay products are formed, they are removed from the body with bile and urine. Part of tetracycline comes out with bile in an unchanged state, then it again enters the bloodstream. This process is called recycling. This ability of the substance ensures its long stay in the patient’s body.


by joseph7williams | 2020-09-15 18:51