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the cost of misery Dravyr

Toxicity

Aciclovir may cause nephrotoxicity (crystallization of aciclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of aciclovir therapy. However, there is no well-defined relationship between aciclovir concentrations in the blood and these adverse effects.

Approval Information

DRAVYR CREAM 5% was registered with Health Science Authority of Singapore by ZYFAS MEDICAL CO. It is marketed with the registration number of SIN08338P with effective from 1995-05-09.

Description

A guanosine analog antiviral drug that acts as an antimetabolite. Aciclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. http://rootsdentclinic.com/anti-viral-category/dravyr-acyclovir.html Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.

References

Although best effort has been made to ensure the information provided is correct and updated, users are advised to visit HSA Official website whenever in doubt. Please see Disclaimers. We Dravyr all the content error reporting/feedback. Please contact us Dravyr Text Us!

Hepatic, Acyclovir is metabolized Dravyr 9-[(carboxymethoxy)methyl]guanine (CMMG) Dravyr 8­ hydroxy-acyclovir (8-OH-ACV) by oxidation and hydroxylation. It is suggested in studies that acyclovir is first metabolized to acyclovir aldehyde by alcohol dehydrogenase and then converted to CMMG. The build up of acyclovir aldehyde may Dravyr the cause of acyclovir-induced nephrotoxicity in the absence of crystalluria.

DRAVYR TABLET 400mg

Source of information: Drugbank (External Link). Last updated on: 3 rd July 18 *Trade Name used in the Dravyr below may not be the same as the HSA-registered product.

acyclovir cream - topical, Zovirax

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It is a Presciption Only Medicine which can only be obtained from a doctor or a dentist, or from a pharmacist with a prescription from a Singapore-registered doctor Dravyr dentist.

Approval Information

DRAVYR TABLET 400mg was registered with Health Science Authority of Singapore by ZYFAS MEDICAL CO. It is marketed with the registration number of SIN08308P with effective from 1995-08-25.

DRAVYR CREAM 5%

Source of information: Drugbank (External Link). Last updated on: 3 rd July 18 *Trade Name used in the content below may not be the same Dravyr the HSA-registered product.

Mechanism of Action

Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir Dravyr the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. One may consider aciclovir to be a prodrug as it is metabolized to more active compounds. Aciclovir is selective and low in cytotoxicity as the Dravyr thymidine kinase of normal, uninfected cells does not use aciclovir effectively as a substrate.


by joseph7williams | 2019-12-15 23:35 | Comments(0)